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KMID : 0369819790090010115
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Jorunal of Korean Pharmaceutical Sciences
1979 Volume.9 No. 1 p.115 ~ p.119
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The Intestinal Absorption of Lysino - Methylene - Ampicillin in Rat
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진금섭/Chin KS
김종갑/김재백/Kim JK/Kim JB
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Abstract
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The absorption rate of lysino-methylene-ampicillin from the rat small intestine, compared with ampicillin, was determined in vitro and in situ to establish the biopharmaceutical properties of lysino-methylene-ampicillin which is one of the new penicillinase-resistance antibiotics. The half of administered dose was absorbed rapidly within thirty minutes. The water-oil distribution coefficient of lysino-methylene-ampicillin was 0.03 in chloroform versus buffer system with Na2HPO4?citric acid of pH5.2 at 37?C, and its dissolution rate reached the plateau in an hour and then represented 0.6 percent of equilibrium solubility
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